A piece of artwork painted by David Bowie is expected to fetch up to £55,000 when it comes to auction for the first time.

Sotheby’s said the 1996 self-portrait by the musician, who died aged 69 on January 10, 2016, after an 18-month battle with cancer, will go on sale next week.

Bowie, whose 80th birthday is being marked with celebrations in London, made the piece "during a prolific period of painting in the mid-1990s”.

The creation belongs to a small group of portrait heads produced at that time". After Bowie gifted the painting to his St Ives gallerist, it remained in the same collection until now.

It is expected to bring between £35,000 to £55,000 at Sotheby’s Modern British & Irish Art Day Auction in London on Thursday, October 15.

Sotheby’s called the work on paper "one of the most striking and personal self-portraits by David Bowie ever to appear at auction", noting it contains his likeness alongside two handprints pressed directly on to the composition.

The auction house said: “Staring directly out at the viewer, Bowie prominently displays his famously asymmetric eyes, while the handprints in the lower corners create an unusually intimate connection to the artist.”

It added: “More than a self-portrait, it’s arguably the closest thing to a physical trace of Bowie himself that a collector could own.”

The work is “particularly noteworthy” as “very little” has been published about Bowie’s painting practice.

Sotheby’s said: “There is no catalogue raisonne or definitive record of this body of work. As a result, examples appearing at auction are exceptionally rare.

“In fact, only two Bowie self-portraits have previously come to auction. Compared to those works, this piece is remarkably direct in its gaze, more vividly coloured and arguably far more commanding in its presence, making it one of the strongest Bowie self-portraits to emerge publicly to date.”

Bowie’s longtime art adviser and curator Kate Chertavian said: “Though David’s love of the visual arts has been widely celebrated, his life as a painter remains relatively unknown.

“So here we get a rare glimpse of David as a visual artist in his own right. I was very much part of his world when he created the series of eight self-portraits to which this work belongs.

“He painted them in London – sometimes at a studio in my house, and sometimes in his hotel rooms. He was prolific, producing prints as well as paintings, but these self-portraits are among my favourites – they capture the essence of David.”

Bowie had five number one singles and 11 number one albums in the UK during his lifetime, and is best known for songs such as Space Oddity, Ashes To Ashes and Sound And Vision.

He released his final album, Blackstar, on his 69th birthday, two days before his death in 2016.

It became his first album to reach number one in the US, topped charts in more than 20 countries, and won five Grammy Awards.

Last week it was announced that a series of special events, releases, collaborations and fan experiences had been launched around the world to mark what would have been his 80th birthday on January 8 next year.

Titled Bowie80, organisers say the events will acknowledge how Bowie’s impact can still be “seen, heard and felt across all forms of art and in mainstream and outsider culture spanning both the 20th and 21st centuries”.