
Scientists from said nuclear conflict could kill 133 million people by 2100.
Their new report also listed the 17 major dangers to human health over the next 75 years, including high alcohol use, antimicrobial resistance and climate change.
The Commission reached its conclusions by modelling how many years might be lost to sickness, disability, or early death due to each threat, known as disability-adjusted life years (DALYs).

The experts predicted that in a worst-case scenario, nuclear war could wipe out 9.35 billion DALYs.
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The risk of malicious AI could also cause humans to lose 10.4 billion years of good health this century.
The other catastrophic threats could cause more than 1 billion DALYs.
The 17 dangers to human survival by 2100
Extinction-potential threats:
- The malicious use of artificial intelligence (AI)
- Nuclear conflict
Catastrophic threats to health:
- Air pollution
- Declining development assistance for health
- Naturally occurring pandemics
- Antimicrobial resistance
- High alcohol use
- Childhood malnutrition
- High blood pressure
- Poor mental health
- Climate change
- Income inequality
- Conventional conflict
- Low educational attainment
- Unhealthy ageing
Obesity was named as one of the worst health burdens on humans this century, contributing to 23.1 billion DALYs by 2100.
Income inequality could impose an amenable health burden equivalent to 25 COVID-19 pandemics, The Lancet scientists fear.

The health experts’ key focus is encouraging world leaders to act to combat these 17 interlinked threats.
For example, they argue that faster progress on improving education for women and children in sub-Saharan Africa could stop the loss of 16.1 billion healthy years.
If politicians limit global warming to 1.8C, instead of letting it reach 4.4C, the report argues that 1.89 billion DALYs could be saved.
Commission co-chair Professor Christopher JL Murray said: ‘The striking finding is not only the scale of these threats, but that humanity still has the agency to act.
‘Across all 17 catastrophic threats, the decisions made by leaders today will shape the health and wellbeing of the next generation.
‘But delaying action will only serve to shift and increase the costs into the future.’
He continued: ‘Crucially, all 17 threats are interconnected, which is why they must be addressed together, not in isolation.’
The scientists have three demands for the world to be better prepared to meet the catastrophic threats coming its way.
These are building readiness to manage these threats, back scientific breakthroughs and innovation, and better tracking of potential threats as the century unfolds.
Commission Co-Chair Dr. Kanem said‘Recent global events show us just how quickly stability can give way to crisis, and how costly it is to respond only after disaster strikes.
‘And the global threats to health risk amplifying existing inequalities, with the greatest burden falling on the most vulnerable communities. Yet the future is not inevitable.
‘The Commission makes a compelling case for reshaping the future by embedding foresight into decision-making. Governments and communities must act decisively starting today, to protect health and build a fairer, more peaceful and more secure future for the coming generations.’
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